I know, I enjoy CL quite a bit. I actually currently have REPLs running for a few services, because I like managing them from the inside. But while you
can, if you want, deploy major changes by redefining a bunch of stuff on production servers without version control or backups, you...should not.
It's really nice to be able to redefine classes while you're playing around- but CL's handling of class redefinition just isn't up to snuff on a production server. It's just like doing live changes to your schema, only you see, rather more so. Compared to scp->shutdown->mv->start, if you can possibly tolerate <10s of downtime, or the many existing solutions for gradual rollout if you can't, it just doesn't make sense.
If you had to pick between having REPL access in production and REPL access locally, would it be close? Because I value being able to mess around with a REPL while developing thousands of times as much as I like a neat toy in production. And that ability is exactly what Python or Ruby or Erlang give you. Technically lacking compared to the full suite? Perhaps. But we're talking 0.999, not 0.5.