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Reminds me a little of Dick Hamming's two questions:

1. What are the most important problems in your field?

2. Why aren't you working on them?

Of course, that hinges on the assumption that "your field" is what you're currently working in. For most people, it isn't and will never be.

A similar question then:

1. What are the most important problems in your life.

2. Why aren't you working on them?