Datomic Cloud is slow, expensive, resource intensive, designed in the baroque style of massively over-complicated CloudFormation astronautics. Hard to diagnose performance issues. Impossible to backup. Ran into one scenario where apparently we weren't quick enough to migrate to the latest version, AWS had dropped support for $runtime in Lambda, and it became impossible to upgrade the CloudFormation template. Had to write application code to export/reimport prod data from cluster to another—there was no other migration path (and yes, we were talking to their enterprise support).
We migrated to Postgres and are now using a 10th of the compute resources. Our p99 response times went from 1.3-1.5s to under 300ms once all the read traffic was cut over.
Mother Postgres can do no wrong.
Still, Datomic seems like a cool idea.