Absolutely.
Actively disqualifying people that are not a good fit is a vital part of any business. The people that get easily annoyed are going to be a huge pain at every step, while the real customers buy silently.
Also, when people have a true need, the pop-up is not an annoyance. I do agree that "subscribe to our newsletter" is not a great pitch, but it's a problem of content, not of method. If you get a pop-up on a website offering you a solution of a pressing problem you have, that pop-up is not an annoyance, but an opportunity.
And finally, even if one would be interested in measuring how many of these annoyed visitors there are, that's not really something you can measure. Conversions, instead, are a concrete metric.