> > 1. Use more whitespace
> This depends on who you are designing it for.
As someone who uses fullscreen magnification, all the excessive negative space that is trendy in a lot of contemporary UX design (e.g., in Microsoft Teams) is difficult to deal with. The more space there is between everything, the harder it is to tell 'where I am' when I'm zoomed in. Higher information density is easier to navigate spatially when your visual window of context is smaller, whether that's because you're using full screen magnification or because you're physically moving closer to your monitor and concentrating.
Similarly, the more screen space is wasted on negative space in windows whose main function is to present something to me (PDF viewer, shared screen or PowerPoint window during a video call), the more I have to rely on external magnification software instead of in-app zooming or scaling, which makes everything blurry (pixelated) and ugly.