A good example is the obsession with "fast" web frameworks on your application servers, completely ignoring the fact that your database will be the first to give up even in most "heavy" web frameworks' default configurations without any optimization efforts.
One thread FTW. :)
If that happened at the SaaS company I worked at previously, it would be a bloodbath. The churn would be huge. And our customer's customers would be churning from them. If that happened at a particularly inopportune time, like while we'd been raising money or something, it could potentially endanger the company.
(I'd like to stress again this is not a criticism of HN/dang, but just to illustrate a set of requirements where huge AWS spends do make sense.)