It's much harder to hit any buttons because you can't just speedily mouse over it, you have to use visual feedback to inch on it. And it causes much more stress and strain on your hand, wrist, elbow, eyes and everything. No matter what mouse hardware you are using. The same mice work very well in Windows and Ubuntu. The OS X drivers just suck. I've tried USB overdrive, mouse settings and everything. The basic lag just doesn't go away.
Too bad some keyboard shortcuts like for scrolling work really bad in OSX too - the cursor stays in one place when going up or down pages meaning you have to use the mouse.
The cursor jumping is another crazy issue indeed. You never know where it is going to be once you go over a certain speed threshold.
(Writing this from OS X. Otherwise it's quite nice.)
Caveat: I used to play Quake where the difference between 60 and 77 FPS is life and death. Everybody used high rate CRT:s and clocked their mice to 500 Hz or so. Here's a real mouse test: http://www.esreality.com/?a=post&id=1265679 . I'm annoyed at the mushy interfaces that electronics could have gotten rid of decades ago. It's somehow just a less stressful situation to take photos or browse them in a camera with less delay for example.
Strangely on some installations it doesn't seem to come into effect. For example, I have never noticed it on a MacBook using the touchpad. And I could have sworn it was not there when I first installed Snow Leopard.
But right after installing Lion I had to spend the first few hours hunting down utilities to get the mouse back into a usable state...
If you grew up with one system, the other is horribly broken and I'd argue nearly impossible to learn. I'm a graphic designer who used Windows for years at work without ever "getting used to it", even if I never came home and touched my Mac. Now I work full time at home and it's heaven to have a mouse/cursor that does what I want it to do.
That is, until I installed Team Fortress 2 for office LAN party. Having played it on Windows, it was a world of difference - OS X version seemed so inaccurate, even after getting rid of acceleration.
I find the same thing happens when playing console games and the "look" stick acceleration curves are completely different between games. It is disorienting until you get your bearings and adjust to the speed and acceleration of each input system.
Just as switching between Windows and OS X means switching from CTRL to CMD, you kind of have to go with the flow on mouse speed, acceleration, and so on.
I play in Mac OS X and I use a Razer Deathadder 3G Spawn. No extra drivers.
However, I tried wiggling the mouse pointer and I can't see a lag on my iMac, but if I grab a Finder-window and wiggle it left-right very fast I think there's actually some lag.
I can't really compare TF2 to Windows since in Windows I use the Razer drivers. But yeah, the mouse in TF2 in Windows feels a bit more "glued on".
Edit: Just tried the Explorer-wiggling in Windows and it too felt a bit laggy.
That would introduce about 8ms of "lag" if you're really dialled in and able to perceive it.
I also had Ubuntu at home and at my parents' place, and it had the same simple responsive mouse as Vista.
Now I've gone full Mac but it still constantly annoys me at work. If it weren't for the other good things in the OS...
Just from anecdotal evidence from someone who can detect the lag with 3 different mice, it's not there with the trackpad.