Hacker News Reader

Yeah interesting question, though losing weight via caloric restriction is probably still a big positive effect

Unclear, but some really preliminary research suggests it might actually neuroprotective [1] and cardioprotective [2]. A lot more research needs to be done though, it seems.

[1] https://pubmed.ncbi.nlm.nih.gov/36191807/

[2] https://pubmed.ncbi.nlm.nih.gov/36515811/

It's also associated with thyroid tumors so I'd consider it a life shortener for that alone.

That so far hasn't been documented in humans. Also, being overweight is a life shortener itself, so the question is just which is riskier on-balance.

Fuck me, I hadn't heard about these. Those are some scary side effects.