They generally do, but when you drop something like "I'm a research chemist" on them, they freeze up. In most jobs, there's a certain commonality of experiences. Oh, tell me about your craziest customer stories, or the worst meeting you ever flew across the country for, or whatever. When you have a job that doesn't fall into an "office work" category... that isn't going to work out. Since most people aren't great or even good conversationalists, they're going to fire off a lame joke and hope it's not a total disaster.
I'm an anesthesiologist. If I never hear another family member say "you're going to need a really big hammer to knock him/her out", I'll join the church of whatever god made that happen. In purely social situations, though, I know it's a conversation-killer, because most doctors don't know much about what I do, let alone laymen. So I have a small repertoire of ways to redirect the conversation back to "let's get to know each other a bit" topics. I think anyone in an unusual (but not, on its face, fascinating) job does.