For a Node example, with esbuild, I can no longer ever install packages and assume they will work fine when running under the host (macOS) and Docker VM (Linux).
Unless Pydantic is downloading all OS binaries with the package and loading the right one at runtime, this would become a "problem" as well. For those coming strictly from scripting language land, this could screw up their workflow quite a bit. A lot more of these people have never worked with native binaries than you think.
I, like many here, understand this basic nuance and would rather my tools be fast. However, I think this is quickly eroding the value of using a dynamic scripting language. The platform portability advantage is completely removed as stuff like this spreads and it makes working with those scripting languages a pain in the ass to the point I wouldn't even want to use a scripting language anymore. It becomes totally opaque whether or not your code can actually run on another target.
In my case this is OK, but I think I'm in the minority.