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You couldn’t tie your shoelaces in 4D because the laces would just slip around each other.

You can't knot 1-dimensional curves in 4-dimensions, but you can knot 2-dimensional surfaces.

Therefore, a 5D being ties their shoes with 3D universes.

New twist on the simulation argument: we're living in the shoelaces of someone's high-tech shoes.

A 6D being even! We live from aglet to aglet.

Aren’t some organic molecules effectively knots? Though I imagine there are plenty of alternatives.