Not if you're young and healthy. Older people get less mobile and stiff when it's 15c inside though. And for health purposes it is suggested to not let the temperature get below 16c due to issues with moisture and mould.
Wife teaches exercise classes for the older 50’s and this is a cyclical problem. High temps mean less movement is required to keep warm which leads to loss of muscle mass and lower mobility, which requires higher temps to keep warm and so on….