The shorter later novels are not difficult but don't bring the full banquet. I still really enjoy them. As a character my wife and were quite fond of Maxine in Bleeding Edge. I immensely enjoyed Against the Day, which is big enough to get the full effect but not quite as anarchic. As with Ulysses, I hated it when it 'ended'. Keep going, the ride's fantastic! Mason & Dixon has got the dialect problem, which has to be mastered to grok what's going on.
I didn't find The Crying of Lot 49 that difficult. However I am still annoyed after 4 decades I notice post horns too easily.