Ask HN: Can stress resilience be chemically modulated?

I'm curious if we know of anything that can work prophylactically to alter neurochemistry and render someone resistant to psychological stress and burnout. For example, could that be done with an SSRI (even for someone who isn't depressed)? Are there other drugs out there that could in theory (safely) reduce someone's vulnerability to stress?

I'm aware of practically every lifestyle modification that might be of use here, so interested specifically in pharmacological options.