My impression is that the notion of "virtual particles" is a bit of an outdated concept. There isn't really as much of a physical distinction between "real" and "virtual" particles as there is sometimes made out to be. All particles are excitations of some underlying field. Generally speaking, these excitations can have some resonance that allows them to persist for long durations. This resonance occurs when the particle is "on the mass shell" in the jargon --- that is, it has a rest mass that is equal (or at least extremely close) to the observed mass of the particle. Excitations that are "off the mass shell" decay exponentially. But these other excitations do have real observable effects. The Casimir effect is the most famous, but they're also responsible for the Lamb shift and Hawking radiation which have also been observed.