Importantly, the issue why my ideas were boneheaded was that typically there’s a lot of unknown side functions and ramifications in biology which are easily overlooked. Glp-1 based drugs weren’t discovered by deliberate hypothesis testing. Sglt2 inhibitors might be but given the number of trials it took in attacking metabolic syndrome using “logic” (avoid fat, avoid sugar, inhibit fat uptake, eat sugar substitutes, etc). This just eeems like a fluke more than merit of following simple logic into complex hormonal systems.
This is true in all medicines. Except antibiotics almost no effective medicine was “invented” by applying first principles the way you would in physics, even if initially it looked like that’s how it worked. Take chemotherapy for example. If the drug works effectively by killing all dividing cells completely, it clearly should kill you, but it doesn’t. It just kills cancers. But that’s because turns out our immune system plays a pivotal role in chemotherapy effectiveness.