> I don't think misgendering people is a "defining characteristic" of Republicans and if that is, the Republican Party is in a pretty sad state considering all the bigger problems in the world.
Some religious conservatives are convinced that referring to a transgender person by their preferred pronoun is a sin, even a serious one, for which they will be judged by God. Even religious conservatives who don't personally subscribe to that viewpoint, see it as one they are morally obliged to respect and defend. [0] While that doesn't describe all Republicans, obviously there is a significant overlap between Republicans and religious conservatives. And for a devout religious person, their religious beliefs are one of their defining characteristics–they are a huge part of their life, even their very identity, who they understand themselves to be.
Even those conservatives who think it is okay to use a person's preferred pronouns, will adopt a much more restricted stance on the topic than many trans activists. Many will insist on it must be voluntary rather than mandatory, and defend the freedom of conscience of those who take a more conservative stance than they do – which is an expression of both religious and political beliefs about respect for individual freedom and conscience.
Some conservatives are willing to use a friend/colleague/acquaintance's preferred pronouns when interacting with them, but will refuse to do the same for a criminal in the news. Look at Wikipedia to see people who vehemently insist that you must use the preferred pronouns of a dead school shooter or executed murderer – and even if the family of the victims publicly objected to it, that wouldn't change their mind.
> Banning polygamy would be discriminatory against Mormons is one. You could even argue that a full abortion ban is discriminatory against Jewish people.
Prohibitions on discrimination are never absolute, they always permit exceptions – so the existence of exceptions is not an argument against the existence of the prohibition. And whatever the merits of those specific examples, they are actions, not speech. Society traditionally gives religious minorities far greater latitude with respect to their beliefs about what they can and can't say, than their beliefs about actions which aren't predominantly expressive in character. Jehovah's Witnesses who believe it is a sin to salute flags or recite pledges of allegiance, Quakers who believe it is a sin to swear oaths, etc.
> >some jurisdictions also have laws against discrimination on the basis of political belief.
> Notably not in the US where Twitter is based and were most of these complaints originate.
While the US currently lacks federal laws banning political discrimination, state and local laws sometimes do ban it, see [1]. Some of those laws are specific to certain contexts (e.g. housing or employment), and so may not be applicable to a social media platform such as Twitter. However, given increasing concern among conservatives about political discrimination, it seems rather likely that we'll see more state laws enacted on that topic in the future.
[0] Examples: https://www.gotquestions.org/transgender-pronouns.html https://www.ncregister.com/commentaries/stand-fast-on-the-pr... https://seekersguidance.org/answers/modesty/should-i-honour-...
[1] https://reason.com/volokh/2021/10/18/bans-on-political-discr...