As a wise programmer once said: "Lisps are created by those who are lazy to write proper parsers"

Homoiconicity does not mean your syntax should be backwards. Look at Io language: it is basically a Lisp, but it has parens in the familiar places.

Same with Forth: it is a small and powerful language, but it's good for implementing low-level stuff. You will quickly run into desire to have normal(language(with, familiar, syntax)) for writing non-trivial programs.