It really depends who you are, but NSAIDs also have their fair share of potential dangers. They are particularly linked to higher risks of heart attacks and strokes [1], but also ulcers and in rare cases other problems.

As for me, whenever I take an NSAID (including Aspirin), my chest feels like it's going to explode. It's not a painful feeling, but it is not a good feeling. It also sometimes gets difficult to breathe. And it's been this way my entire life, so I shun them completely.

As for acetaminophen, the dangers mainly stem from overdose, overuse, and using it with alcohol consumption. Avoid that and it's pretty safe.

[1] - https://www.mayoclinic.org/diseases-conditions/heart-attack/...

Ibuprofen is generally considered safer than Acetaminophen BUT non-steroidal anti-inflammatory drugs (NSAIDs) like Ibuprofen can trigger dangerous stomach acid over production in some patients (source: finding myself in excruciating pain followed by a doctor pushing a camera probe down my throat to examine the damage when this happened to me). That's a minority of patients, obviously, but there are classes of patients who need to take Acetaminophen instead of NSAIDs for various reasons.

Acetaminophen is similar to NSAIDs in many of its beneficial effects but is sufficiently different chemically as to not trigger many of the (rarer) negatives that NSAIDs can trigger.