The episodes are really hit or miss. I really enjoyed the interviews with John Carmack and with Guido van Rossum. I started several other episodes that I just bailed on, though, and it's a big time investment just to get to the point where you realize you are wasting your time. So at this point I won't go out of my way to listen to episodes but I will go listen to one when it's getting talked about elsewhere.
The less Lex is talking and the more the person he's interviewing is talking, the better.
BTW if anyone who enjoyed the van Rossum and Carmack interviews has any suggestions on other episodes I might like, I'd love to have them.