I weight train regularly. Lots of forearm tension. I noticed one day that it always hurt more when I was scrolling (using an original Apple Magic Mouse). Brutal repetitive strain injury. However, when I went for periods of time only using the trackpad in my MacBook, my arm would feel
Upon realization, pretty much immediately switched to a trackpad at my desktop as well, and problems went away.
It took about 18 months to get from "my arm really fucking hurts" to "yeah, it was the mouse". People always ask why I use a trackpad at a desktop, I tell this story. I don't remember the last time I used a mouse on my computer.