This reminds me of the EOMA68 project[1], which was seeking to use the same connectors to build systems where you simply swapped out compute cards when they got old and slow, saving on e-waste. I mostly like the idea of having the option to swap between a 'light' ARM processor board for general browsing, and a beefy x86 + GPU board for CAD work. With the dawn of PCIe being used for SD card data transfer, I think that even an unmodified reissue would work out quite well.

[1] https://elinux.org/Embedded_Open_Modular_Architecture/EOMA68