If you've done Node.js with TypeScript (or even JS), you may want to consider C# and .NET Web APIs. C# and TS are syntactically similar.

.NET minimal web APIs are very similar to Express in setup (at least initially; you layer in middleware as needed).

You can get an API up and running in Google Cloud pretty quickly.

Short video here: https://www.youtube.com/watch?v=GlnEm7JyvyY (< 7 minutes to get a minimal web API into Google Cloud Run with no special tooling involved).

Entity Framework (ORM) is pretty good and supports a variety of databases (SQL Server, Postgres, MySQL, others). Working with JSON is low-friction.