We got extremely lucky that it's super hard to separate the isotopes of uranium and plutonium that can be used to make an A-bomb from the minerals that can be mined on Earth surface. If it was easier to do every dictatorship and every terrorist group like ISIS would build a nuclear arsenal and the biggest remaining city on Earth today would be probably 10,000 people.
We got lucky with nuclear chain reaction, but who knows what weapons of mass destruction will become possible with further advances in physics, biology, material science, AI. A discovery that will make it possible for a small group of extremists to destroy the human civilization may be the Great Filter.