Why the downvotes?
TRULY Big problems:
Every year 15 million children die of hunger. ... 1 in 5 children in Africa die of malaria ... 1 million people die of malaria
I would hardly classify "having to fill out the same form every time I go to the Doctor's office" as a "BIG" problem.
We lack the will to pay for it and the ability to distribute it effectively in the midst of corrupt/brutal governments without empowering said governments. I'd argue that solving the latter is a Big Problem although not one I imagine a for-profit company solving.
Your comment is the direct reason for this.
When you say "big," you appear to mean "severe and life-threatening". When he says it, he appears to mean something like "broad in scope, requiring an extremely complex solution."
Malaria prevention doesn't really fit the latter definition, though it does fit the unrelated definition you're using.