July 28, 1957, two nukes jettisoned from airplane into the Atlantic, never recovered. February 5, 1958, bomber collides mid-air, jettisons nuke off coast of Georgia, never recovered. July 6, 1959, cargo plane crashes on takeoff, explosives do not go off in the fire. January 24, 1961, bomber catches fire while in air, two hydrogen bombs dropped over North Carolina, one comes close to detonation.
And on, and on, and on. America in the Cold War kept nuclear weapons continuously aloft along the Soviet border, but the program experienced so many crashes that it had to be scuttled. In the final one, the nuclear payload ruptured: https://en.wikipedia.org/wiki/1968_Thule_Air_Base_B-52_crash