Big-time cognitive dissonance there.
Big-time cognitive dissonance there.
Behavioral problems, etc make reproducibility harder.
When we can overcome those problems, like with cultured cells, most prefer human cell lines.
But the intention is to have a "model" rather than the full thing.
And why is that a problem? More research, more study material. In the two generations you'll have a cure+extra compared to a single dedicated animal study, that may not even work on humans. Loosely speaking.
Rat: easy for you to say.
Also, this was the plot of Shinsekai Yori.
Phase 1 trials are to test safety and possibly design input for the next (phase 2) trial. In particular in oncology, there is no expectation that a patient in phase 1 will even potentially benefit from an experimental drug but there will likely be (detrimental) side effects in the high-dose groups at which point we back off.
So let's acknowledge that many of the (more modern) drugs we take are also a result of fairly heroic consent from human patient volunteers without any chance of personal gain.