I expect one of the future frontiers in systems research (OS, compilers, etc) to be in this area: scaling things like file caches, prefetching, memory arenas, gc invocation (and gc types), thread pools, ...
They all need to be regulated, somehow, for best performance. Unfortunately, nobody really knows how to do that except in small isolated cases. What is even more unfortunate: very few of the people working in this area seem to know anything about control theory.