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Engineering Explained did an episode especially on the topic [1], it seems a huge amount of routes could indeed be replaced by an electrical semi.

[1] https://www.youtube.com/watch?v=hvg_i0GE0Vo

Currently weight matters because there are laws on the maximum weight of certain kinds of trucks.

However, I believe that with a good lobbying team, those laws could be changed if an EV truck maker could demonstrate they can do less damage to the road with a heavier truck, for example with better traction control and more drive wheels. Or maybe just wider wheels and lower or even variable tyre pressures.

Most trucks aren't at their weight limit. There will be electric trucks that can carry moderate loads for long distances and others (with smaller batteries) that can carry heavy loads for shorter distances. For heavy loads and long distances, you could use the latter and charge it more often, but you should just put it on a train.