Hospital’s iced water machine purifier stripped out chlorine, killing 3 patients
arstechnica.com
arstechnica.com
How cool is it that in 2023 you can sequence samples from 4 patients as well as bacterial cultures found in separate ice machines and water sources to identify the source of an infection. Almost 30 years ago, when the first bacteria was sequenced, or 20 years ago, when the human genome project finished at a cost of $2.7B, or even 10 years ago, when sequencing cost more than $10,000 per run, this would have been unfathomable. But today it's a $600 routine expense, and it's perfectly reasonable to perform a dozen of them in the course of a large study.
I got very severe sinus infection post sinus surgery from a incredibly rare Mycobacterium. (as far as I know I'm the only person in the world documented to have this bug in my sinuses)
It took almost 9 months to beat, 6 months with 3 types of antibiotics going at once.
The aggressive antibiotic caused severe neutropenia and put me back in the hospital for 16 days.
My infectious disease specialist basically equated treating mycobacterium infections similar to chemo.
Glad this episode is behind me, but never forget that tap water is not sterile.
Sort of like winning the lottery but in reverse. Sorry you had to go through that. Not just a reminder about tap water, but also not to have sinus surgery unless you really need it. I've heard from too many people that say even if it helps for awhile, the polyps usually grow back. I wonder if the success rates have improved recently.
After my first surgery my polyps were back worse than they started in just 3 weeks after the surgery (due to the infection... which hadn't been detected yet).
The doctors decided it was something unique with my immune response and said that the mycobacteria culture taken during the first surgery was a false positive. 2nd and 3rd opinions said the same thing!
Decided to have a 2nd surgery and mycobacteria came back in the culture again and they once again said it was a false positive/lab contamination... which is hard to prove until the culture has reached maturity.
Lab came back and it was indeed mycobacteria.
Honestly it is my go-to when I have a really bad flare up.
Which isn't a problem in most cases, but in this case it was also a case of an improperly cleaned machine; it apparently relied on some chlorine in the water to limit bacterial colonies. I think that would be fine overall, but only if the machine was emptied and thoroughly disinfected regularly. I can imagine a machine like that would also be a source of legionella.
Over here, after a major legionella incident [0] got 318 people sick of which at least 32 died, they're paying a ton more attention to it with things like public fountains, but they also seal firehoses nowadays - they would on occasion be used for utility like hosing things down, but then be unused for a long time, causing legionella and other nasties to build up in the room temperature water contained in the hoses.
[0] https://en.wikipedia.org/wiki/1999_Bovenkarspel_legionellosi...
What is with all the hatred for Chlorine? Putting it in water is one of the great lifesavers, right up their with cooking and antibiotics. I hear people tell me about its health impacts, that it is "going to give cancer" and other crazy stuff. Well, as a former competitive swimmer, if chlorine does any harm whatsoever I am a write off. Having soaked in chlorinated pools for thousands of hours, and no doubt also drank in a not-small amount of that water, any hypothetical health impacts would have ended me decades ago. Stop filtering it.
Ignorant people.
Less dickishly - people incapable of assessing risks as a spectrum alongside other risks - combined with a giant echo chamber in everyone's pocket.
The tap water tasted fine in everyone one of them.
¯ \ _ ( ツ ) _ / ¯
The most disgusting water I taste consistently is from a plastic bottle.
In your defense, there's a big difference between room temp, tap cold, and chilled water. At room temp there is a flavor of water. Chilled with ice or a fridge mutes flavors.
If you did a blind taste test of chilled tap and "filtered" chilled water you wouldn't be able to tell a difference. Consequently, if you did the same test at room temp, you'd find both to have bad flavors.
Also, when you fill a pitcher of water and let it stand, the chlorine evaporates, so you don't actually like chlorine - you always make sure to remove it :)
1. Chlorine tastes nasty in water. (The correct solution IMO here is to use chloramine instead.)
2. Chlorine removal may be a side effect. Carbon filters are used to remove all kinds of nasties and/or unpleasant tastes and odors. And they remove chlorine. Carbon-filtering without removing chlorine may be difficult or impossible.
> Well, as a former competitive swimmer, if chlorine does any harm whatsoever I am a write off.
Research is mixed, but the actual danger to swimmers might not be the chlorine per se. There is some (conflicting) evidence that nitrogen trichloride and/or dichloramine exposure increases asthma risk in swimmers and in people who work near indoor swimming pools. They also smell terrible — the nasty “chlorine” smell, especially around indoor pools, is dichloramine and nitrogen trichloride.
Fortunately your tap water is unlikely to meaningfully expose you to these. You need a nitrogen source and excess chlorine, which should not exist at the same time in any substantial amount in tap water. A chlorinated swimming pool plus sweat and/or urine is a different story.
Completely unrelated other harvard medical news, their resident union is getting some major concessions from the administrators right now. That’s pretty cool. Pay at some of these progressive institutions is completely inadequate.
The article says:
> Although hospital records indicated that the machines had been maintained and cleaned per the manufacturer's instructions, the researchers noted visible bacterial biofilms on the inside components of the machines.
But it seems like a hospital should have its own standards for cleaning and disinfecting, not relying on manufacturer cleaning instructions for a non-medical device being used for patients with highly elevated risk of infection.
It makes me wonder how many (or few) hotels keep on top of this kind of maintenance.
But, any source of food and water should be subject to frequent testing, it should have flagged up much sooner than this. This also applies outside of hospitals, the dodgy looking ice machines in e.g. hotels probably don't get tested at all.
Here’s a manual for an ice machine:
https://www.webstaurantstore.com/documents/pdf/hid_manual.pd...
See page 19. I don’t know whether 10 minutes of exposure to 100ppm sanitizer will kill a biofilm adequately. Even “ppm” is vague. 100ppm of (active) hypochlorous acid is quite high and ought (IMO) to sterilize things effectively. But the recommended sanitizer is Stera Sheen Green Label, which, like most powdered sanitizers, is based on dichlor. 100ppm free chlorine worth of dichlor also adds about 90ppm of cyanuric acid, and cyanuric acid buffers hypochlorous acid, such that 100ppm FC + 90ppm CYA is a much worse disinfectant than 100ppm FC by itself.
Also, what disinfects the tubes between the filter and the reservoir?
(Why isn’t chlorine dioxide used for this purpose more often? It’s supposedly much better than chlorine for killing biofilms. Possibly less damaging to plastics as well.)
It's one of the reasons I returned to being a computational biologist.
It's the total opposite of "practically nothing", it does exactly what I bought it for -- effectiveness 100%.
I find it strange you're insisting filters don't work when one can tell from taste that they clearly do. And scientifically, activated carbon absorbs chlorine -- that's not a myth. So everything checks out.
Pitcher filters work for chlorine.
I think most people buy filter pitches to fix the taste of water. Not for health or safety reasons.
Similar issues exist in most 'older' US cities. I started becoming worried about my water filter efficacy after moving to downtown DC and learning that a significant portion of the municipal water supply's last mile piping contains lead, and that while the municipal water is safe at the source, water in DC housing is often heavily contaminated by lead and other compounds resulting from the use of extremely aged pipe infrastructure.
Cheap filters improve taste, not water quality. And in most places that's all you need.
It's an even bigger risk, generally, with pitcher/reservoir type systems (e.g. Brita or Pur) that require manual fills, given that they get a lot of environmental exposure. If you use a Brita pitcher for a while and then leave the filter media and pitcher somewhere at room temp for a couple weeks, you can often see evidence of fungal/microbial growth popping out of the bottom of the filter cartridge. It's pretty gross. I've also had a relative end up in the hospital with a pretty severe amoebic infection, which investigators traced back to her Brita filter cartridge she had neglected to change for some time.
And if you leave almost anything out at room temperature for weeks kept moist you're going to see gross growth. It's nothing specific to a filter.
But this is why you replace your Brita filter every 2-3 months and wash the container.
Refrigerator filters generally need to be replaced every 6 months.
It's both because they lose effectiveness and because bacteria builds up inside them.
And your ice maker is normally always cold.
But clean any parts that do get warm.
Sounds more like incompetence especially you are in a hospital setting
Shouldn't the UV light also kill bacteria, though?
Another thing I never quite understood was how bacteria thrive in purified water anyway, to the point where they can form biofilm. Where do they even get the necessary nutrients?
Anyway I have not found any suitable answer for cleaning the water pipes after these strip everything out of the water filter systems, and whilst it shouldnt be a problem if you have copper pipes throughout the house because copper kills most bacteria and some viruses, hence copper water vessels from the past, if you have the new plastic flexible piping in the house, cleaning will almost certainly be required.
Penicillin based antibiotics when they are broken down in the liver become penicillamine and this causes the body to release lots of copper into the blood stream, so how much is that having an antibacterial effect on the body? Plus copper is also needed for interleukin-6 which kills alot of cancer, so if doing lots of penicillin antibiotics, your risk of cancer could go up if your dietary copper intake is not high! Something the medical professionals dont tell you!
So something like what the pubs use to flush their pipes leading up from the barrels and kegs should do it for cleaning the water system pipes after the water filter, but like I say, I havent found anything satisfactory from these household water supply filter people. Certainly copper pipes are best though, and if doing some DIY, dont leave any flux on the pipe because in damp cold conditions, condensation reacts with the flux and it causes tiny pinholes to form in the pipe. A good plumber will clean their pipes down to stop this from happening otherwise you get minute water leaks that can get worse very quickly.
UV-C is the main disinfecting UV light source, but you dont want to go near it because UV-C destroys pretty much anything which is why most of it is blocked in the upper atmosphere.
I know hospitals use it to clean wards and rooms, but it will destroy materials much more quickly, ideally hospitals would clean a ward and room like normal to remove ground on dirt and then use the robots that move around shining UV-C all over the place.
FWIW, the main sanitizer used for kegs is the same thing used in restaurants for the standard "three sink" cleaning system (last dip is in sanitizer). Star San is the main brand name. It's a mild acid and it's both cheap and readily available. It works basically by denaturing proteins, which any acid will do, but the specific one is chosen to be harmless and relatively tasteless as well as easily clinging to surfaces to give extra contact time.
I'm not sure it would be a good idea to use it, though, as it might eat away at some plumbing fixtures (e.g. galvanized pipe).
If you did, you'd want the non-foaming variety (which is not called star san... Saniclean, I think? Same brand, either way).
https://finance.yahoo.com/news/insane-golden-chamber-contain...
scroll down to the "Terrifyingly pure water" section for a fun read on how fun really pure water can be.
It doesn't take much for bacteria or fungi to start growing on previously filtered water once it's open to air. Just take a glass of filtered water and leave it out for a few weeks. Some glasses won't grow anything. Others will have all sorts of things floating on the surface.
Pasteur is credited for formalizing this knowledge when he figured out that if you used a crooked necked flask to store media, it reduces the chance of airborne contamination.
Once bacteria form a biofilm, it could make it more difficult for any chlorine or UV light to disinfect or sanitize the surface. The bacteria have formed a sort of protective bubble.
Mycobacteria are particularly good at resisting various antibiotics because they have a thicker than average cell envelope. Mycobacterium tuberculosis is another bug in this family.
It doesn't matter if you purify water then expose it to room air. It's going to get contaminated again.
Since the other machines elsewhere didn't have these filters, it's safe to assume nobody had them on the maintenance list and serviced them.
No conspiracy theory needed.
Ice machines are notoriously filthy because they have tons of tiny spaces that never dry. I remember looking inside an ice machine at work and the inside was covered in a thin film of slime.
Edit: however it seems that the machines were maintained, so it might not be about this specifically.
> Both carbon filters and ultraviolet light are known to decrease chlorine concentrations.
Seems crazy, right? That's why I'm asking.