A number of games simulates unique agents: Tropico, Rollercoaster Tycoon, Theme Hospital, Two Point Hospital, Ceasar 3 / Cleopatra etc. etc.
Its a different game entirely compared to games like Sim City or City Skylines. I've noticed that these "individual agents" games are very "unstable". They're only designed for a limited number of agents before everything goes to crap.
As such, "individual agent" games tend to be scenarios that you play for a short time, rather than trying to play for months on the same map (like Sim City or City Skylines or OpenTTD can be).
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Tropico Boom/Busts grow too variable and uncontrollable. You'll eventually have an island-wide boom/bust collapse that probably triggers the instant-loss endgame (aka: Soviets and/or USA invades).
Ceasar 3 / Cleopatra are reasonably stable, but definitely a smaller map and designed for scenario play instead.