I want to love zellij but can't get over how it binds its own actions to practically every key (vs screen/tmux which take just one, the prefix). Do people who use it not use any programs that use control or alt keys?
That said, I must admit that zellij doesn't add a whole lot to my workflow relative to tmux. I think I'm just easily distracted by the new-and-shiny.
Zellij has Lock interface, default Ctrl+G, which you can use and in that mode it only takes that one key, but it's a bit different from how screen works.