My company provides me with the laptop, VPN connection to the office network, which, in turn, connects to our (tiny) datacenter, where actual work happens (i.e. compilation, CI, testing, all happen there).

Sometimes I work from the office, other times from home.

The datacenter has several "jump" servers having distinct roles, there is a server that lets you connect to our OpenStack cluster, another has some resources to run a bunch of unrelated VMs in KVM, yet another one is the storage for all kinds of artifacts, s.a. Linux packages, Linux distro images, Docker images for development and testing, and then there's CI cluster.

So, my typical setup is like this: I have an ansi-term buffer per jump server. The jump servers are running my tmux session. So, every time I have to move my laptop to a different network (eg. going home from office), I reconnect to the jump servers and to the tmux session they were running so that I can pick up from where I left off before disconnecting from office VPN.

If TRAMP could have a persistent session, maybe, I'd not use tmux (I don't like that I have different commands for managing buffer appearance and clipboard). On the other hand, tmux is more universally used (at least in my company), so that sometimes I can simply ask a colleague to connect to my session, if they need to investigate some strange situation (only a handful of people are using Emacs, but almost everyone would be able to use tmux at where I work).