Top caffeine drinkers are smokers with mental illness
futurity.org
futurity.org
The two main paths for tryptophan metabolism are [majority] niacinamide/kynurenine synthesis and [minority] serotonin synthesis.
Heavy niacinamide/kynurenine demand diverts tryptophan from serotonin production, leads to chronically low serotonin.
And while there is a non-trivial amount of caffine coming from other places like tea, or Monster energy drinks, I'd bet my hat that most of N. America is drinking coffee more than any other caffeinated beverage.