Assuming you know enough about what they're doing to actually dig in - which, granted, maybe you're only considering interviewing people who are working things you're somewhat familiar with.
Ultimately, I don't see how this is different from a technical design interview - in that you can be susceptible to hiring charlatans, and pass on people who'd rather say they don't know something than try to BS most of it on the spot to sound impressive.
The two people could have the same knowledge. You're more likely to hire the charlatan. Maybe that's what you want :shrug: