Yeah, the fundamental physics constraints of this approach are pretty wild. The cross section peak for the candidate Proton-Boron interaction is at about 10 times higher energy (i.e. temperature) and the peak itself is roughly a fifth of the Deuterium-Tritium cross section. Oh and each individual interaction produces less than half the energy. So 100x more difficult is actually not far off in that sense. That means you don't just need a lot more energy to sustain the reaction, you'll also get a lot less energy from it. This is a very long and steep road to net energy production and there are good reasons why noone has bothered with it so far. The only upside is that you produce more charged particles, which are easier to control and extract energy from and they also cause less radiation damage. But if anyone ever makes a reaction like this work, by bet is still on Helium-3. But we won't be able to make use of that until we have scalable mining industry on the moon's surface.