Running a denoising filter through ReShade or ffmpeg (or better yet with VapourSynth post processing for non live streaming) can help.
In fact, hardware encoders have excellent built in denoising (and other postprocessing) functions. But they are so obscure that less than a dozen streamers on the planet are probably using them... I cant even remember the syntax now, I would have to go look it up in Staxrip and then see if it even works in OBS :/