I leave my personal Windows 10 desktop running for about a month at a time so I don't have to reopen 5 different windows and arrange them across three screens for uni work every evening. It works fine.
Mind you, if it was a Mac I'd not even have to reopen or arrange them after restarting the machine - they'd still be there. Although my work Mac loves to randomise which display gets which windows and desktop background... And randomly pan all bluetooth audio to the left ear once a week. I guess all OS's have their issues.