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The one side effect I’ve heard from my doctor who has patients on LDN, that fortunately seems fairly rare, but that can catch people off guard is sudden depression. People a few days to a week into starting it suddenly having uncontrollable crying and other things. Apparently corrects quickly after stoping so not something to be afraid of so long as aware. LDN seems to help a lot of people.

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I think this is a reversal of emotional blunting. I consider becoming overly emotional a good indication that LDN will really help and heightened emotional sensitivity will wear off as the brain adjusts. Stiff like crying over spilt milk. Certainly people should be warned that they could be in for a bit of an emotional roller coaster.

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