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Comment by erentz | Hacker News Reader

This is quite interesting to me also. I have a neuro and inflammatory disease with elevated liver enzymes since getting sick. It seems TUDCA is fairly safe.

How does one calculate their dose?

Looks like I need to find a reputable brand and seller, that's lab made (rather than bear bile) if anyone has suggestions.

EDIT: Okay this is quite shocking to me so had to share, in searching for reliable sources of TUDCA it looks like pharmaceutical versions are now being approved in Canada and the US for treatment of ALS that cost $13,000 per month!

https://biopharma.media/amyotrophic-lateral-sclerosis-new-dr...

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TUDCA is not perfectly safe. Studies show that while it does prevent damage from ethanol and AAS abuse when taken during or after, it can also cause/exacerbate damage when taken prior to ethanol/AAS or by healthy individuals.

Long term TUDCA use seems like it also lowers good cholesterol.

What is AAS?

Anabolic steroids, it’s popular in that community as a harm reduction supplement for liver support.

To be clear, if you’re not taking alcohol/ethanol etc then TUDCA seems fairly safe for short term use

For <8 weeks, yes. But year-round general supplementation for no indicated reason can be harmful. TUDCA is known to lower HDL cholesterol (good cholesterol).[0]

NAC would be a more appropriate year-round liver support for general supplementation.

0: https://pubmed.ncbi.nlm.nih.gov/8674405/

Even that has issues. It can promote lung cancer growth and initiation. The gist is it is too good at keeping cells alive and keeps alive some that should have died.

https://www.science.org/content/blog-post/n-acetyl-cysteine-...

NAC chelates metals like zinc and copper, so you got to watch out for low levels of those when supplementing NAC.

Oh that’s not good. Thanks for letting me know.

> In early January 2022, Amylyx has submitted a Marketing Authorization Application (MAA) for Relyvrio/Albrioza to the European Medicines Agency (EMA).

I hope this wont end the same way like edaravone.

Most brands you can buy online are not made from bear bile. But since it’s an expensive supplement, there’s lots and lots of counterfeit (in my experience). I never buy off eBay or Amazon market place, but directly from manufacturers. Some I‘ve tried and which seem to work for me: BodyBio, Everychem, Nutricost

Buy tudca from purebulk or any bulk type stores and have it tested in a lab which is fairly easy process . If it's 99% pure changes in dosage won't need to change much

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