After the great Gmail exodus two years ago (when they killed then unkilled legacy domain accounts), I moved to MXRoute — and the amount of unfiltered spam I get is insane. It's a daily nuisance. I have added about 200 filter words now, blocked hundreds of e-mail addresses, but it's next to impossible to filter out sometimes.
From conversations and threads online by the MX Route admin, it seems like this is a nearly unsolvable problem, still. Spam evolves so fast and uses throwaway one-time approaches only, so once you've filtered for a pattern, the next campaign looks completely different.
So, yeah, sorry about the long response, but I don't think Spam has been solved, at all, at least not if you're using an e-mail that's been around for longer than a few years (and appeared at least in one leak).