Show me homoiconicity used "for real". Sure, it's useful in compilers and interpreters, but how often do people need them in a business application? You will most likely use a library, and/or a syntax designed for serialization instead of programming, like JSON.
I personally vastly prefer Python's syntax over Lisp's, because the parentheses require two buttons pressed (shift + 9) instead of one (tab). That may sound trivial, but it's why I jump to Python instead of a Lisp.
That said, I do suffer from Python problems: the GIL, clunky immutable data structures like pyrsistent, poor support for shared memory for multithreading and so on.
Edit: I just realized in Lisp you could replace the built-in data structures if you wanted, so libraries like pyrsistent would require little change in client code syntax. I guess that's one example of homoiconicity in action.
Can you come up with another one? It is not very often that I find myself wanting to redefine the language I'm using (which comes with its risks: other coders and/or their tooling might find my code hard to follow).