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It's all about hardware. I've addressed it quite well with a three-pronged approach:

1. Motorized standing desk - typing from varying postures keeps strain spread out

2. Kensington trackball mouse - less hand sweeping / temptation to drags wrist on table

3. Ortholinear "Planck" keyboard - modifier keys accessible via thumb and programmable layers more generally can completely eliminate painful hand poses and keep fingers on the home-row

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Change is good. I find using a variety of mice helps. Rollermouse, trackpads, rockmouse, carpal tunnel mouse(quadraclicks), mousetrapper.

For the dragging wrist problem, I really like the reloot or other similar gliding palm rests. I find upgrading them with ceramic lights makes a big difference.

Personally I find the Kensington trackball mouse made my carpel tunnel a LOT worse, they're not for everyone.

With my particular RSI I also can't use a standard trackball, but I swear by my thumb trackballs. (But every body is different, every injury is different, etc.)

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