Errm ... about that headline. "The researchers found a difference in how sensory signals are processed in [pyramidal neurons of cortical layer 5]" in a mouse model of Fragile X Syndrome. That's it.

The abstract of the paper ends with "These results challenge the traditional view that FXS and other ASD are characterized by sensory hypersensitivity, proposing instead a hyposensitivity of sensory inputs and hypersensitivity of predictive inputs onto cortical neurons."

And that is under the assumption that any of these hypotheses are true(ish). While an interesting finding, it doesn't prove that it is a significantly contributing factor in (human) autism.