In that sense, I have the impression SQLite is different from other database software. You can usually get by with Postgres or MySQL (after they are set up) without looking at their docs.
I spent several hours reading the SQLite docs. It wasn't wasted time: actually learning SQLite made me a better professional. But for those thinking of using it on their side (or main) project, definitely understand how it works and what are the trade-offs involved.
Now, to answer your question specifically: it depends on a few factors. You can have concurrent readers (wal). With newer developments (wal2 + begin concurrent), you can also have concurrent writes as long as they happen at different pages.
If you are blindly doing multi-threaded connections without understanding the implications, you also risk corrupting the database entirely.