One concern I've heard about UV (and ionization) stuff is that you're adding 'active chemistry' into your ventilation system, which could possibly cause strange reactions you may not want.
Besides 'bugs' and dead skin, there are are VOCs and other chemicals that we use in our homes: how will those reaction? If these units are new and working properly, things may be fine, but how many homeowners will do (or have someone do) regular inspections/maintenance? Having this stuff in non-residential places may be fine because Facilities has a role in keeping HVAC working: regular people don't do that.
Having good filters (MERV ≥13) will get rid of most of stuff you don't want in a simpler fashion.