Once such simple method, which still works, is to short BTC and go long QQQ/SPY during market hours if there is relative weakness of BTC before the market open, whilst going long QQQ/SPY. Both legs are exited at the market close.
This has been very profitable. Even the most advanced firms are bound to miss easy strategies. Pattern recognition, intuition are more valuable when to comes to trading than having more data or better tools.