The last memorable earthquake in the Midwest was the 5.2 "tremor" of 2008 [0] just north of the New Madrid fault. It was felt as far away as Georgia and Nebraska. I recall a scientist quoted as saying that the area "rung like a bell" because it occurred in the stable interior craton. It caused some minor damage like a few bricks falling off a couple buildings. I was working in a 2nd story building and felt the the upper cabinet of my office vibrate a little.
[0] https://en.m.wikipedia.org/wiki/2008_Illinois_earthquake