But I think it's much deeper -- having worked at a couple big companies now, I realize (at least to my limited observations) that the path of a company is set by the deeply ingrained culture that has been established over many years by its founders, by its evolution, its successive leaders, and in fact, the competitive environment in which it operates. Things (good or bad) that last far beyond any one leader.
It manifests in the little incentives that people far below the CEO understand to do their jobs in a certain way, to pursue certain things and decide to drag their feet or ignore certain other things.
If you were hired at a company and worked there for years understanding that if you did <x>, you got <y>, it will be hard to change a whole workforce of that notion, especially when one individual gets beaten back in line if they stray. Even if others want to change just as much. Even if the CEO says to change. It takes years for that info to percolate. Sometimes it never does.
No, sometimes companies need to die in order to be reborn.