2 big issues I have are the tendency to freeze, and then say "restart to keep using Firefox" because it updated in the background and can't continue.
The other was almost a deal breaker, and still could be. When using a barcode scanner, Firefox can't keep up with the characters coming from the scanner. It will randomly drop characters. I spent a lot of time trying to figure out why some scans weren't working, and the scanner works perfectly in Chrome, works perfectly in a text editor and intermittently drops characters randomly in Firefox.
If it were just the start character, or the end character it wouldn't matter so much, but it drops characters in the middle of a barcode. It has for years, it's a known issue, I don't see it ever being fixed.